Perspective: The fix is in
- (27 November 2014)
- Published online
- 26 November 2014
“Herrick’s discovery of sickle cell disease was a pivotal moment in medical history,” Pemberton said. “It stands as a crucial innovation in Western medicine as well as hematology, one that symbolized the power of microscopic analysis and the laboratory to give evidence to a distinctive form of anemia that physicians had previously failed to see among their African-American patients.”
Pemberton, a historian, wrote The Troubled Dream of Genetic Medicine: Ethnicity and Innovation in Tay-Sachs, Cystic Fibrosis and Sickle Cell Disease (Johns Hopkins University Press, 2006). The book received the science award that same year from the Association of American Publishers. Next year, Johns Hopkins University Press will publish his forthcoming book: The Bleeding Disease: Hemophilia and the Unintended Consequences of Medical Progress.
Pemberton will participate in the symposium’s opening panel discussion on historical and cultural perspectives. John Ruffin, director of the National Center on Minority Health and Health Disparities, will moderate. Pemberton’s talk, "Sickle Cell Anemia and the Vexed Crossroads of Race and Disease in America,” will examine health disparities of African Americans over the last century. “African Americans have been at a disadvantage in our healthcare system,” he said. “What historians have done is use sickle cell as a lens into the disparities in the treatment of the disease.”
Physicians and others believe today that the sickle cell trait is prevalent among people of African descent because the trait developed over time as protection against malaria. The trait is not the disease; it’s related to a specific gene. Individuals who inherit it from both parents have a 25 percent chance of developing the disease, a hereditary disorder leading to anemia and treatable by blood transfusions. Affected red blood cells are sickle-shaped, hence the name, and don’t carry oxygen efficiently so that patients experience painful crises as their tissues are starved.
Highlights from Pemberton’s talk include: